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Commitment

Working Together in the Fight Against MS

Bringing Rebif to you

Rebif® (interferon beta-1a), a highly effective treatment, is available to help slow the progression of Multiple Sclerosis. Rebif has been proven to slow the course of relapsing forms of MS, the most common form of the disease, and is the fastest growing treatment for relapsing forms of MS in the US. Rebif is co-marketed by EMD Serono, Inc. and Pfizer Inc in the US.

Ongoing support

EMD Serono and Pfizer support you in your personal fight against MS. Through MS LifeLines®, you can access updates on new MS research, treatment information, ongoing treatment support, educational seminars, and connect with a community of people who are also living with MS.

Continuing research

EMD Serono and Pfizer are committed to helping the MS community and people living with MS. Through research and innovation, the fight against MS continues until a cure is found. EMD Serono and Pfizer are working to develop new therapies that can improve the lives of people with MS.

About EMD Serono

EMD Serono, a global biotechnology leader, is dedicated to developing innovative therapies that fight debilitating diseases and improve the lives of patients. The Company has conducted leading research and product development in the area of multiple sclerosis and other diseases. Serono's growing portfolio of MS products is used to treat both relapsing forms of MS and worsening MS.

About Pfizer

Pfizer Inc discovers, develops, manufactures, and markets leading prescription medicines for humans and animals and many of the world's best-known consumer brands.

Brought to you by EMD Serono, Inc. and Pfizer Inc., the co-marketers of Rebif® (interferon beta-1a) in the US EMD SeronoPfizer

Prescribing Information - Medication Guide

This information is intended only for residents of the United States.

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Efficacy has been established in controlled studies up to 2 years in duration. Rebif is not approved for the treatment of chronic progressive multiple sclerosis. Rebif is available by prescription only in 22 mcg and 44 mcg pre-filled syringes and a titration pack.

Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, and blood count or bleeding problems or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.

Potential serious side effects of Rebif include depression, liver problems, risk to pregnancy, injection site problems and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty breathing and loss of consciousness, which requires immediate medical attention.

The most common side effects with Rebif are injection site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, increased liver enzymes, and blood cell count decreases. Let your doctor know immediately if you have any of these symptoms or feel sad, tired, hot or cold, experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

This information is not intended to replace discussions with your healthcare provider. For additional information about Rebif, please consult the Medication Guide or Prescribing Information and talk to your doctor. You can also call toll free 1-877-44-REBIF (1-877-447-3243). Rebif is available by prescription only.

MS LifeLines is an educational support service for people living with MS and their families. MS LifeLines and MS LifeLines Ambassadors are sponsored by EMD Serono, Inc. and Pfizer Inc.

Rebif, Rebiject II and MS LifeLines are registered trademarks and the Rebif logo is a trademark of EMD Serono, Inc. or its affiliates.

MS in Balance is a service mark of EMD Serono, Inc. or its affiliates.

Copyright 2008 EMD Serono, Inc. All rights reserved.